The following describes the published science behind the technology we use based on the manufacturer's materials and open sources. Face and Body Perfection is a wellness studio, not a medical practice. Our services are not intended to diagnose, treat, or cure any medical condition.
Endospheres® is a professional body and facial treatment system developed and manufactured by Fenix Group srl in Italy. Its core method – Compressive Microvibration® – is patented and has been independently studied by three European universities. The device is used by certified professionals in more than 50 countries.
The Endospheres® handpiece is a cylindrical roller containing 55 silicone spheres arranged in a patented formation. When applied to the body, the spheres rotate against the skin and subcutaneous tissue, delivering three mechanical actions simultaneously. The spheres are removable and can be sanitised between clients.
Fenix Group srl manufactures the Endospheres® device family in Italy. The current generation device – the ESSENZA – is the third generation of the technology, incorporating design and performance refinements over the original platform. All Endospheres® devices are ISO certified.
Three things happening at once. That is the point. Most body treatment devices do one thing. They heat tissue, or they vibrate it, or they suction it. The Compressive Microvibration® method does three things simultaneously – and the combination is what gives it a distinct mechanical profile.
Compression into the tissue.
The 55 spheres press into the skin and subcutaneous tissue at a calibrated depth. This compression reaches below the dermal layer into the fascial network – the connective tissue architecture beneath the surface. As the roller moves across the body, it delivers a rolling mechanical signal through the full depth of the soft tissue it is applied to.
Vibration, layered onto the compression.
Simultaneously with the compression, the spheres rotate at a controlled low frequency. This vibration is not applied to the surface of the skin – it is delivered into the tissue under compression. The effect is a simultaneous mechanical stimulus at the subcutaneous level: compression and vibration in the same moment, at the same site. This combination is what is patented as Compressive Microvibration®. The low frequency is deliberate. Higher frequencies stay at the surface; low-frequency vibration, delivered under compression, reaches the fascial and lymphatic structures below.
Along the anatomical lymphatic routes.
The third action is not a byproduct – it is built into the protocol design. Each session maps the roller along the anatomical lymphatic pathways: from the lower limbs toward the inguinal nodes, from the arms toward the axillary nodes, from the face and neck toward the cervical chain. The compression-vibration action mobilises interstitial fluid, and the directional protocol moves that fluid toward the lymph nodes. This is mechanically driven drainage along real anatomical routes – not general massage.
Tissue drainage, connective tissue stimulation, and circulatory activation each require mechanical input at the tissue level. A device that suctions the surface reaches the dermis. A device that vibrates without compression stays above the fascial layer. Compressive Microvibration® reaches all three targets in one pass because the compression drives the vibration and drainage into the same subcutaneous space.
This is the mechanical logic behind why the Endospheres® clinical studies focused on circumferential measurement, lymphatic function, and skin quality – not just surface appearance. The researchers were measuring what is actually happening in the tissue.
Three universities. One method. Endospheres® Compressive Microvibration® has been studied independently by researchers at three European institutions. These are not manufacturer-sponsored marketing studies – they are institution-based clinical evaluations of the technology’s safety and effectiveness.
The University of Siena, Italy, conducted clinical evaluation of the Endospheres® method. Siena’s medical faculty has longstanding research activity in aesthetic and dermatological treatment science.
Researchers at the University of G. D’Annunzio Chieti, Italy, conducted independent study of the Endospheres® method. This institution is known for research in biomedical sciences and clinical applications.
The Federico II University of Naples – one of the oldest and most prestigious universities in Europe, with a medical faculty dating to the 13th century – independently studied the Endospheres® method.
The full technical dossier for Endospheres® is available directly from Fenix Group srl via endospheres.com. At Face and Body Perfection, we are a certified Endospheres® studio – the device we use is the same platform studied by these institutions.
A separate Endospheres® handpiece is calibrated for the face and neck. The mechanical principles are the same – Compressive Microvibration® – at a pressure and frequency calibrated for the structural characteristics of facial skin: thinner tissue, a more delicate vascular network, and a different anatomical lymphatic map. The facial protocol follows the cervical lymphatic chain toward the submandibular and parotid nodes.
01 40.14% reduction in cellulite severity score after 12 sessions¹
Study: Bacci P.A. – “Thermographic and clinical data (TCD Code) in the evaluation of cellulite treatment by Endospheres Therapy” – Journal of Applied Cosmetology
Methodology: 20 female patients, 12 sessions over 5 weeks, TCD Code composite scoring
02 16.4% decrease in fat mass · 13% increase in skeletal muscle mass · ~15% increase in active cell mass after 12 sessions¹
Study: “Evaluation of the effectiveness of non-invasive methods of compressive microvibration” – Journal of Applied Cosmetology
Methodology: Women aged 40–49, peri/post-menopausal, assessed by bioimpedancemetry
03 Skin improvements confirmed by ultrasound imaging – maintained for 2 months after a 12-session course, no adverse effects¹
Study: “Ultrasonographic Picture of the Skin and Subcutaneous Tissue in the Treatment of Cellulite Using Compressive Microvibration” – Journal of Applied Cosmetology
Methodology: 27 women with mild-to-moderate gynoid lipodystrophy, DUB SkinScanner ultrasound at completion and 60-day follow-up
04 Endospheres compressive microvibration promotes angiogenesis, tissue remodelling via mesenchymal stem cell activation, and cellular metabolic improvement – no reported side effects across reviewed studies
Study: Veronese S., Chirumbolo S., Bacci P.A. et al. – “Biological basis of the aesthetic and rejuvenating effects in the skin after the application of the compressive microvibration Endospheres” – Journal of Applied Cosmetology, University of Verona
Methodology: Systematic literature review; not a clinical trial
COI disclosure: Prof. Bacci is the inventor of the Endospheres device and a co-author
05 A 20-year retrospective scientific rationale covering the mechanism of action of 55 rotating silicone spheres: vascularising, draining, analgesic, and tissue-restructuring responses
Study: Saggini R. (G. D’Annunzio University) + Bacci P.A. (University of Siena) – “Compressive microvibration with ‘Endospheres Therapy’” – Journal of Applied Cosmetology, May 2022 (open access)
Methodology: 20-year retrospective review; not a clinical trial
COI disclosure: Prof. Bacci is the inventor of the Endospheres device and a co-author
06 “Ultrasonographic picture of skin and subcutaneous tissue in treatment of cellulite using compressive microvibration” – Physiotherapy, Balneology and Rehabilitation, No. 6, 2022
View source (EN) →07 “Assessment of effectiveness of compressive microvibration in cellulite treatment” – Physical and Rehabilitation Medicine, No. 3, 2023
View source (EN) →08 “Compressive microvibration in cellulite treatment: what studies say” – Cosmetics & Medicine, No. 3, 2023
View source (EN) →09 “Modern view on pathophysiology of gynoid lipodystrophy” – Pacific Medical Journal, No. 2, 2024
View source (EN) →10 “Laser Doppler flowmetry indicators in assessing microcirculatory correction” – Postgraduate Medical Education Bulletin, No. 3, 2025
View source (EN) →11 “Evidence-based aesthetics: effectiveness of Endospheres in gynoid lipodystrophy” – Kardashova – Medical Almanac, No. 4, 2025
View source (EN) →12 Clinical trials demonstrated postural balance improvements and aesthetic harmony outcomes across Endospheres body treatment patients
Study: Saggini, Scuderi, Bellomo – Clinical monograph, Italy
Context: Clinical monograph – not a peer-reviewed journal publication
13 Compressive microvibration vibrational lymphatic drainage demonstrated clinical benefit in treatment of secondary lymphedema
Study: Sergio Marcini – National Association of Sports Medicine Specialists
Context: Sports medicine clinical review – not a peer-reviewed journal publication
Read the ICOONE® research here →
¹ Individual results vary. Results depend on treatment frequency, starting condition, and individual tissue response.