The following describes the published science behind the technology we use based on the manufacturer's materials and open sources. Face and Body Perfection is a wellness studio, not a medical practice. Our services are not intended to diagnose, treat, or cure any medical condition.
Developed in collaboration with Dr. Jean-Claude Guimberteau – the French surgeon whose in vivo endoscopic research first documented the microvacuolar connective tissue network that Roboderm® was designed to reach. ICOONE® is manufactured by i-Tech Industries® and is the only professional body treatment device built on Roboderm® technology – a patented microstimulation system developed from the connective tissue research of Professor Jean-Claude Guimberteau. It is the only device in its category that applies microstimulation to both sides of the tissue simultaneously.
Professor Jean-Claude Guimberteau is a French plastic and reconstructive surgeon whose in vivo research on living connective tissue – conducted by inserting a fibre-optic camera directly beneath the skin during surgical procedures – produced the first direct observation of the subcutaneous architecture in a living, moving human body.
What he found challenged the anatomical model that had defined surgical and therapeutic approaches to soft tissue for decades. The conventional model treated the subcutaneous layers as organised in horizontal planes: dermis, fat, fascia. Guimberteau’s footage showed something different – a continuous, three-dimensional network of fluid-filled microchambers, bounded by collagen and elastin fibres, arranged not in planes but in a dynamic web.
He named these microvacuoles. Each one is a small space, delimited by collagen and elastin fibres, in a state of constant dynamic balance between tension and compression – what structural engineers call tensegrity. The microvacuoles are not passive containers. They are active structural units that allow the skin and subcutaneous tissue to adapt to pressure, volume change, and movement while maintaining firmness and elasticity.
The published research reference is: Guimberteau, J.C. – The Sliding Mechanics of the Subcutaneous Structures in Man and Illustration of a Functional Unit: The Microvacuoles – both available for download via icoone.com/science.
As microvacuoles lose their dynamic responsiveness – through age, inactivity, chronic fluid stagnation, post-surgical disruption, or rapid body composition change – the skin surface changes in visible ways.
The microvacuolar network can no longer distribute mechanical tension evenly across its web. Areas of rigidity develop. Fluid accumulates in pockets. Collagen and elastin production decreases as fibroblast activity declines without mechanical stimulus. The results are skin laxity, irregular texture, and reduced firmness.
Creams and topical treatments act at the surface of the skin. They cannot reach the microvacuolar network below the dermis. Roboderm® was designed specifically to reach it.
Gianfranco Tudico, working from Guimberteau’s research, designed a device technology that could engage the microvacuolar network mechanically and non-invasively. The result – patented in 2008 – is Roboderm®.
The ICOONE® handpiece contains a matrix of micropores. When applied to the skin, the micropores generate thousands of suction-and-release microstimulations per minute, simultaneously, across the contact area. The key distinction – and what is patented – is that the microstimulation acts on both sides of the tissue at the same time. The tissue is engaged from the surface inward and from below simultaneously, creating a three-dimensional mechanical stimulus that reaches the microvacuolar level.
The frequency, depth, and pattern of microstimulation is adjustable. Aesthetic protocols target the dermis and immediate subcutaneous tissue. Deeper protocols use a different rhythm and pressure to reach the fascial layer.
Sourced from i-Tech Industries® published research at icoone.com/science.
Blood flow and tissue oxygenation.
Roboderm® microstimulation increases local blood flow. The rhythmic suction-and-release action of the micropores dilates capillaries and drives nutrient-rich blood into the tissue. Cells are nourished. Tissue oxygenation increases. The clinical applications noted by i-Tech Industries® include post-traumatic and post-operative contexts where impaired circulation is part of the recovery picture.
Elimination of excess fluid.
The mechanical action of the micropore matrix drives interstitial fluid toward the lymphatic system. Fluid that has accumulated in the tissue – through chronic stagnation, post-surgical swelling, hormonal fluid shifts, or inactivity – is mobilised and directed toward the lymph nodes. i-Tech Industries® notes this application specifically in post-surgical lymphatic drainage and in cases of illness-related fluid accumulation.
Fibroblast activation, collagen and elastin.
ICOONE® microstimulation activates fibroblasts at dermal and subdermal depth. Fibroblasts are the cells responsible for producing collagen and elastin – the structural proteins that give skin its firmness, elasticity, and thickness. Mechanical stimulation of fibroblasts is a well-documented trigger for increased collagen production. The published research on ICOONE® covers this mechanism in the context of scarring tissue, burn recovery, and standard skin ageing.
Subcutaneous repositioning.
Targeted microstimulation of subcutaneous tissue promotes lipolysis – the breakdown of stored fat within adipocytes – and the mechanical repositioning of adiposities within the tissue. The structural irregularities that manifest as uneven skin surface – densified pockets of subcutaneous tissue, localised adiposity – become less pronounced as the tissue is repeatedly stimulated and mobilised. Body contour improves. Skin surface smooths.
15 published studies. Available at icoone.com/science.
i-Tech Industries® maintains a published research library documenting multi-microalveolar microstimulation across aesthetic, post-surgical, oncological rehabilitation, and clinical recovery applications. All studies listed below are available for download directly from the manufacturer. The range of topics reflects the breadth of clinical contexts in which the technology has been formally evaluated – from standard aesthetic reshaping to breast cancer rehabilitation to caesarean recovery.
01 The Sliding Mechanics of the Subcutaneous Structures in Man – Guimberteau
The foundational research establishing the microvacuolar architecture of living connective tissue.
02 Illustration of a Functional Unit: The Microvacuoles – Guimberteau
Defines the microvacuole as the structural unit of connective tissue and the basis for the Roboderm® design principle.
03 Micro Multi Alveolar Stimulation in Mechanised Connective Tissue Massage According to the Theory of the Microvacuole
Documents the application of multi-microalveolar stimulation as a mechanised connective tissue approach.
04 Randomised Clinical Trial on Patient Compliance and the Ergonomics of Two Devices for Mechanized Massage
RCT comparing patient experience and compliance across mechanical massage devices.
05 A New Technology for Connective Tissue Micro Alveolar Stimulation: ICOONE®-H
Introduces the ICOONE® device platform and its technical basis in connective tissue microstimulation.
06 Stroma and its Cosmetic-Functional Reactivation: Multi Micro Alveolar Stimulation, A Revolution in Evolution
Addresses stromal tissue reactivation through multi-microalveolar stimulation; cosmetic and functional outcomes.
07 Intermittent Microalveolar Stromal Stimulation Therapy: Lower Legs Functional and Cosmetic Reshaping by Lympho-Venous Network Activation
Covers ICOONE® application for lower leg reshaping through lympho-venous activation.
08 The Fibres, Extracellular Matrix and Cells Observation Under the Action of the Multi Micro Alveolar Stimulation on Normal and Scarring Tissues
Histological observation of how ICOONE® microstimulation acts on both normal and scar tissue at the cellular level.
09 Multi Micro Alveolar Stimulation Combined with Laser 915nm and LED 650nm for Skin Regeneration and Firming Effect
Studies the combined effect of ICOONE® with laser and LED for skin regeneration and firming.
10 The Power of ICOONE® Medical Microstimulations in Breast Cancer Rehabilitation
Documents ICOONE® Medical application in breast cancer rehabilitation – lymphatic, scar, and tissue recovery context.
11 A Journey Under the Skin Through ICOONE®
Visualisation and narrative of the subcutaneous action of ICOONE® microstimulation; illustrative companion to the Guimberteau framework.
12 Mobilisation, Vascularization and Metabolic Exchanges
Covers how ICOONE® microstimulation drives mobilisation of tissue structures, vascularisation, and metabolic exchange at the cellular level.
13 Multi Micro Alveolar Stimulation: The Unique Three-Dimensional Stimulation from the Outside to the Inside and the Clinical Results
Characterises the three-dimensional nature of Roboderm® stimulation and the corresponding clinical outcomes.
14 The Clinical and Aesthetic Advantages of Using Multi Micro Alveolar Stimulation During Recovery from Caesarean Section
Covers ICOONE® application in caesarean section recovery – scar remodelling, lymphatic drainage, and tissue quality.
All studies listed above are published by i-Tech Industries® and available at icoone.com/science. Face and Body Perfection does not hold or distribute the full study texts. The links on the ICOONE® manufacturer website lead to downloadable PDFs. If a specific study is relevant to your situation, we recommend downloading and reviewing it directly.
01 ICOONE’s Multi Micro Alveolar Stimulation acts on the microvacuolar structure of connective tissue, stimulating lymphatic drainage, tissue regeneration, and microcirculation – demonstrated effectiveness across cosmetic and medical applications including burns, keloids, and peripheral oedema
Study: Palmieri B., Lodi D., Corridori I. – “A new technology for connective tissue micro alveolar stimulation: ICOONE®-H” – Gazzetta Medica Italiana, 2008;167:311–338
02 ICOONE microstimulation therapy produced objective and subjective improvements in cosmesis and microcirculation in lower legs – strongest results in patients under 40¹
Study: Palmieri B., Aspiro A., Sighinolfi G. et al. – “Intermittent microalveolar stromal stimulation therapy: lower legs functional and cosmetic reshaping by lympho-venous network activation” – Minerva Chirurgica, 2019;74(Suppl.1 al N.3):1–7
03 In a published case series, ICOONE combined with a minimally invasive procedure produced an average 1.5 kg reduction in upper arm fat mass; physicians rated outcomes as Good to Excellent¹
Study: Nilforoushzadeh M.A. et al. – Clinical Case Reports, 2026;14:e72243
† Case series of 3 patients; results reflect a combined treatment protocol – not ICOONE as a standalone
04 ICOONE’s Multi Micro Alveolar Stimulation technology outperforms traditional vacuum therapy in preserving skin elasticity, firmness, and microvascular integrity¹
Study: Comparative MMAS vs vacuum therapy – bioRχiv preprint (2024), randomised crossover, 20 women aged 30–60
‡ Preprint – pending peer review. Results are preliminary.
05 In a monocentric randomised trial, patients reported improvement in skin quality, systemic effects, and psychological wellbeing – ICOONE rated favourably on ergonomics by physiotherapists
Study: Scuderi N., Troccola A., Fioramonti P. – “Randomised Clinical Trial on Patient Compliance and the Ergonomics of Two Devices for Mechanized Massage” – La Sapienza University, Rome
Clinical white paper – no peer-reviewed journal publication confirmed
06 ICOONE Medical microstimulation is used clinically in post-breast cancer rehabilitation to reduce scar fibrosis, manage lymphoedema, and improve tissue trophicity
Study: Rolland J. – Kiné Actualité, N°1593, 16/09/2021
Published in French physiotherapy trade journal; author declares conflict of interest as an ICOONE protocol developer
Read the Endospheres® research here →
¹ Individual results vary. Results depend on treatment frequency, starting condition, and individual tissue response.
† Case series of 3 patients; results reflect a combined treatment protocol – not ICOONE as a standalone.
‡ Preliminary findings – preprint pending peer review.